Detailed view for OVOC8925

Basic information

TDR Targets ID: 983787
Onchocerca volvulus, Transmembrane protein 131 homolog
Source Database / ID:  Wormbase Parasite  

pI: 9.3103 | Length (AA): 335 | MW (Da): 39125 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12371  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
49 149 2h28 (A) 28 122 29.00 0.27 0.29 0.314599 -0.11
93 193 2e6j (A) 9 111 13.00 0 0.11 0.194699 -0.49
97 189 2ys4 (A) 28 118 26.00 0 0.92 0.352239 -0.24
1208 1667 4k6j (A) 659 1173 11.00 0 0.02 0.29781 -0.11
1280 1341 4leb (A) 134 195 13.00 0 0.01 0.16996 -0.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134135)

Species Accession Gene Product
Brugia malayi Bm1_01020   hypothetical protein
Caenorhabditis elegans CELE_C27F2.8   Protein C27F2.8
Drosophila melanogaster Dmel_CG8370   CG8370 gene product from transcript CG8370-RA
Homo sapiens ENSG00000075568   transmembrane protein 131
Loa Loa (eye worm) LOAG_08170   hypothetical protein
Loa Loa (eye worm) LOAG_11630   hypothetical protein
Loa Loa (eye worm) LOAG_11629   hypothetical protein
Mus musculus ENSMUSG00000026116   transmembrane protein 131
Onchocerca volvulus OVOC8925   Transmembrane protein 131 homolog
Schmidtea mediterranea mk4.000384.16   Transmembrane protein 131
Schmidtea mediterranea mk4.000384.17  

Essentiality

OVOC8925 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C27F2.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_C27F2.8 Caenorhabditis elegans larval arrest wormbase
CELE_C27F2.8 Caenorhabditis elegans larval lethal wormbase
CELE_C27F2.8 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform 309 aa 33.7% 312 aa Compounds References
Oryctolagus cuniculus Serine/threonine protein phosphatase PP1-alpha catalytic subunit 330 aa 41.7% 295 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC8925 (Onchocerca volvulus), Transmembrane protein 131 homolog
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